Aside from having enough disk space to defragment a disk, choosing a slower time of the day to defragment a disk, and perhaps running the disk check utility before you defragment, I want to know if it is okay to defragment a Windows server or workstation using Microsoft’s disk defragmenter.
A consultant we use happened to see the Microsoft disk defragmenter running on several of our servers, and said running the defragmenter could cause problems. However, the consultant offered no reasons why or any corroborating evidence. I’ve been defragmenting disks for over a decade with no apparent negative results. More or less the Microsoft Devnet community said it’s OK, but I am still looking for the definitive answer to this question.